Translational efficiency explained

In cell biology, translational efficiency or translation efficiency is the rate of mRNA translation into proteins within cells.

It has been measured in protein per mRNA per hour.^[1] Several RNA elements within mRNAs have been shown to affect the rate. These include miRNA and protein binding sites. RNA structure may also affect translational efficiency through the altered protein or microRNA binding.^[2]

See also

• List of cis-regulatory RNA elements
• Transterm
• UTRdb

External links

• http://mrna.otago.ac.nz/Transterm.html Transterm database online

Notes and References

1. Schwanhäusser. Björn. Busse, Dorothea . Li, Na . Dittmar, Gunnar . Schuchhardt, Johannes . Wolf, Jana . Chen, Wei . Selbach, Matthias . Global quantification of mammalian gene expression control. Nature. 473. 7347. 337–342. 10.1038/nature10098. 21593866 . May 2011. 2011Natur.473..337S . 205224972 .
2. Lu. YF. Mauger. DM. Goldstein. DB. Urban. TJ. Weeks. KM. Bradrick. SS. IFNL3 mRNA structure is remodeled by a functional non-coding polymorphism associated with hepatitis C virus clearance.. Scientific Reports. 4 November 2015. 5. 16037. 26531896. 10.1038/srep16037. 4631997. 2015NatSR...516037L .