Transient neonatal diabetes explained

Transient neonatal diabetes mellitus (TNDM) is a form of neonatal diabetes presenting at birth that is not permanent. This disease is considered to be a type of maturity onset diabetes of the young (MODY).

Types

Type	OMIM	Gene	Locus	Description
TNDM1		ZFP57, PLAGL1	6p22.1, 6q24.2
TNDM2		ABCC8	11p15.1	Due to the mutations of the other subunit of the KATP channel, SUR1, which is encoded by the ABCC8 gene.^[1]
TNDM3		KCNJ11	11p15.1

Cause

This condition has to do with genetics and is often associated with having an added Chromosome 7 gene (mostly from the paternal side).

The form on chromosome 6 can involve imprinting.^{[2] [3]}

See also

• Permanent neonatal diabetes mellitus

Further reading

• GeneReview/NIH/UW entry on 6q24-Related Transient Neonatal Diabetes Mellitus

Notes and References

1. de Wet H, Proks P, Lafond M, etal . A mutation (R826W) in nucleotide-binding domain 1 of ABCC8 reduces ATPase activity and causes transient neonatal diabetes . EMBO Rep. . 9. 7. 648–54. May 2008 . 18497752 . 10.1038/embor.2008.71 . 2475326.
2. Book: Raphaël Scharfmann. Development of the Pancreas and Neonatal Diabetes. 10 November 2010. 2007. Karger Publishers. 978-3-8055-8385-5. 113–.
3. Web site: Other Forms (MODY, LADA, Neonatal). www.DiabetesCare.net. DiabetesCare.net. 20 November 2014. Neonatal Diabetes Mellitus.