Trans-resveratrol di-O-methyltransferase explained

Trans-resveratrol di-O-methyltransferase
Ec Number:	2.1.1.240

Trans-resveratrol di-O-methyltransferase (ROMT, resveratrol O-methyltransferase, pterostilbene synthase) is an enzyme with systematic name S-adenosyl-L-methionine:trans-resveratrol 3,5-O-dimethyltransferase.^[1] This enzyme catalyses the following chemical reaction

\rightleftharpoons 2 S-adenosyl-L-homocysteine + pterostilbene (overall reaction)

(1a) S-adenosyl-L-methionine + trans-resveratrol

\rightleftharpoons S-adenosyl-L-homocysteine + 3-methoxy-4',5-dihydroxy-trans-stilbene

(1b) S-adenosyl-L-methionine + 3-methoxy-4',5-dihydroxy-trans-stilbene

\rightleftharpoons S-adenosyl-L-homocysteine + pterostilbene

The enzyme catalyses the biosynthesis of pterostilbene from resveratrol.

Notes and References

1. Schmidlin L, Poutaraud A, Claudel P, Mestre P, Prado E, Santos-Rosa M, Wiedemann-Merdinoglu S, Karst F, Merdinoglu D, Hugueney P . A stress-inducible resveratrol O-methyltransferase involved in the biosynthesis of pterostilbene in grapevine . Plant Physiology . 148 . 3 . 1630–9 . November 2008 . 18799660 . 2577258 . 10.1104/pp.108.126003 .