Trans-feruloyl-CoA synthase explained

trans-Feruloyl—CoA synthase
Ec Number:	6.2.1.34
Go Code:	0050563

In enzymology, a trans-feruloyl—CoA synthase is an enzyme that catalyzes the chemical reaction

ferulic acid + CoASH + ATP

\rightleftharpoons trans-feruloyl-CoA + products of ATP breakdown

The 3 substrates of this enzyme are ferulic acid, CoASH, and ATP, whereas its two products are trans-feruloyl-CoA and products of ATP breakdown.

This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The systematic name of this enzyme class is trans-ferulate:CoASH ligase (ATP-hydrolysing). This enzyme is also called trans-feruloyl-CoA synthetase.

References

• Narbad A, Gasson MJ . Metabolism of ferulic acid via vanillin using a novel CoA-dependent pathway in a newly-isolated strain of Pseudomonas fluorescens . Microbiology . 144 . 1397 - 405 . 9611814 . 10.1099/00221287-144-5-1397 . 5 . free .
• ((Pometto AL III)), Crawford DL . 1983 . Whole-cell bioconversion of vanillin to vanillic acid by Streptomyces viridosporus . Appl. Environ. Microbiol. . 45 . 1582 - 5 . 6870241 . 5 . 242504 .