Trans-aconitate 2-methyltransferase explained
| trans-aconitate 2-methyltransferase |
| Ec Number: | 2.1.1.144 |
| Cas Number: | 235107-12-7 |
| Go Code: | 0030798 |
In enzymology, a trans-aconitate 2-methyltransferase is an enzyme that catalyzes the chemical reaction
S-adenosyl-L-methionine + trans-aconitate
S-adenosyl-L-homocysteine + (E)-3-(methoxycarbonyl)pent-2-enedioate
Thus, the two substrates of this enzyme are S-adenosyl methionine and trans-aconitate, whereas its two products are S-adenosylhomocysteine and (E)-3-(methoxycarbonyl)pent-2-enedioate.
This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:(E)-prop-1-ene-1,2,3-tricarboxylate 2'-O-methyltransferase.
Structural studies
As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code .
References
- Cai H, Clarke S . 1999 . A novel methyltransferase catalyzes the methyl esterification of trans-aconitate in Escherichia coli . J. Biol. Chem. . 274 . 13470 - 9 . 10224113 . 10.1074/jbc.274.19.13470 . 19 . free .
- Cai H . Strouse J . Dumlao D . Jung ME . Michael E. Jung . Clarke S . 2001 . Distinct reactions catalyzed by bacterial and yeast trans-aconitate methyltransferases . Biochemistry . 40 . 2210 - 9 . 11329290 . 10.1021/bi0022902 . 7 .
- Cai H, Dumlao D, Katz JE, Clarke S . 2001 . Identification of the gene and characterization of the activity of the trans-aconitate methyltransferase from Saccharomyces cerevisiae . Biochemistry . 40 . 13699 - 709 . 11695919 . 10.1021/bi011380j . 45 .
