Trans-2-enoyl-CoA reductase (NADPH) explained

trans-2-enoyl-CoA reductase (NADPH)
Ec Number:	1.3.1.38
Cas Number:	77649-64-0
Go Code:	0019166

In enzymology, a (NADPH) is an enzyme that catalyzes the chemical reaction

trans-2,3-dehydroacyl-CoA + NADPH + H⁺

\rightleftharpoons acyl-CoA + NADP⁺

Thus, the three substrates of this enzyme are, NADPH, and H⁺, whereas its two products are acyl-CoA and NADP⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is acyl-CoA:NADP+ trans-2-oxidoreductase. Other names in common use include NADPH-dependent trans-2-enoyl-CoA reductase, reductase, trans-enoyl coenzyme A, and trans-2-enoyl-CoA reductase (NADPH). This enzyme participates in fatty acid elongation in mitochondria and polyunsaturated fatty acid biosynthesis.

References

• Mizugaki M, Nishimaki T, Shiraishi T, Kawaguchi A, Okuda S, Yamanaka H . Studies on the metabolism of unsaturated fatty acids. IX. Stereochemical studies of the reaction catalyzed by trans-2-enoyl-coenzyme A reductase of Escherichia coli . Journal of Biochemistry . 92 . 5 . 1649–54 . November 1982 . 10.1093/oxfordjournals.jbchem.a134091 . 6759504 .