Trans-2-enoyl-CoA reductase (NAD+) explained

trans-2-enoyl-CoA reductase (NAD+)
Ec Number:	1.3.1.44
Cas Number:	77649-64-0
Go Code:	0050343

In enzymology, a trans-2-enoyl-CoA reductase (NAD+) is an enzyme that catalyzes the chemical reaction

trans-2,3-dehydroacyl-CoA + NADH + H⁺

\rightleftharpoons acyl-CoA + NAD⁺

Thus, the three substrates of this enzyme are trans-didehydroacyl-CoA, NADH, and H⁺, whereas its two products are acyl-CoA and NAD⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is acyl-CoA:NAD+ trans-2-oxidoreductase. This enzyme is also called trans-2-enoyl-CoA reductase (NAD+). This enzyme participates in butanoate metabolism.

References

• Inui H, Miyatake K, Nakano Y, Kitaoka S . Tokyo . Purification and some properties of short chain-length specific trans-2-enoyl-CoA reductase in mitochondria of Euglena gracilis . J. Biochem. . 100. 995 - 1000 . 3102464 . 4 . October 1986.