Trans-2-decenoyl-(acyl-carrier protein) isomerase explained

Trans-2-decenoyl-(acyl-carrier protein) isomerase
Ec Number:	5.3.3.14
Cas Number:	9030-80-2

In enzymology, a trans-2-decenoyl-[acyl-carrier protein] isomerase is an enzyme that catalyzes the chemical reaction

trans-dec-2-enoyl-[acyl-carrier-protein]

\rightleftharpoons cis-dec-3-enoyl-[acyl-carrier-protein]

Hence, this enzyme has one substrate, trans-dec-2-enoyl-[acyl-carrier-protein], and one product, cis-dec-3-enoyl-[acyl-carrier-protein].

This enzyme belongs to the family of isomerases, specifically those intramolecular oxidoreductases transposing C=C bonds. The systematic name of this enzyme class is decenoyl-[acyl-carrier-protein] Delta2-trans-Delta3-cis-isomerase. Other names in common use include beta-hydroxydecanoyl thioester dehydrase, trans-2-cis-3-decenoyl-ACP isomerase, trans-2,cis-3-decenoyl-ACP isomerase, trans-2-decenoyl-ACP isomerase, and FabM.

References

• Brock DJ, Kass LR, Bloch K . 1967 . Beta-hydroxydecanoyl thioester dehydrase. II. Mode of action . J. Biol. Chem. . 242 . 4432 - 40 . 4863740 . 19 .
• Bloch K . 1969 . Enzymatic synthesis of monounsaturated fatty acids . Acc. Chem. Res. . 2 . 193 - 202 . 10.1021/ar50019a001 . 7 .
• Marrakchi H, Choi KH, Rock CO . 2002 . A new mechanism for anaerobic unsaturated fatty acid formation in Streptococcus pneumoniae . J. Biol. Chem. . 277 . 44809 - 16 . 12237320 . 10.1074/jbc.M208920200 . 47 . free .
• Neidhardt, F.C. (Ed.), Escherichia coli and Salmonella: Cellular and Molecular Biology, 2nd ed., vol. 1, ASM Press, Washington, DC, 1996, p. 612-636.