Topterone Explained

Topterone (developmental code name WIN-17665), also known as 17α-propyltestosterone (or simply propyltestosterone) or as 17α-propylandrost-4-en-17β-ol-3-one, is a steroidal antiandrogen that was first reported in 1978 and was developed for topical administration but, due to poor effectiveness, was never marketed.^{[1] [2] [3] [4] [5] [6]}

See also

• Steroidal antiandrogen
• List of steroidal antiandrogens

Notes and References

1. Book: Elks J . The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. 14 November 2014. Springer. 978-1-4757-2085-3. 1–.
2. Ferrari RA, Chakrabarty K, Beyler AL, Wiland J . Suppression of sebaceous gland development in laboratory animals by 17alpha-propyltestosterone . The Journal of Investigative Dermatology . 71 . 5 . 320–323 . November 1978 . 712108 . 10.1111/1523-1747.ep12529809 . free .
3. Book: Rasmusson GH . Chapter 18. Chemical Control of Androgen Action . Annual Reports in Medicinal Chemistry . 1986 . 21 . 179–188 (183) . 10.1016/S0065-7743(08)61128-8 . https://books.google.com/books?id=qsFCGskRHZQC&pg=PA183 . Academic Press. 978-0-08-058365-5.
4. Ferrari RA, Chakrabarty K, Creange JE, Beyler AL, Potts OG, Schane HP . Endocrine profile of topterone, a topical antiandrogen, in three species of laboratory animals . Methods and Findings in Experimental and Clinical Pharmacology . 2 . 2 . 65–69 . April 1980 . 7339330 .
5. Chakrabarty K, Ferrari RA, Dessingue OC, Beyler AL, Schane HP . Mechanism of action of 17 alpha-propyltestosterone in inhibiting hamster flank organ development . The Journal of Investigative Dermatology . 74 . 1 . 5–8 . January 1980 . 7351494 . 10.1111/1523-1747.ep12514560 . free .
6. Book: Marsden JR, Shuster S . The Treatment of Acne . Pharmacology of the Skin II: Methods, Absorption, Metabolism and Toxicity, Drugs and Diseases. https://books.google.com/books?id=GvDxCAAAQBAJ&pg=PA490. 6 December 2012. Springer Science & Business Media. 978-3-642-74054-1. 490–.