Tirucalladienol synthase explained

Tirucalladienol synthase
Ec Number:	5.4.99.56

Tirucalladienol synthase (PEN3) is an enzyme with systematic name (3S)-2,3-epoxy-2,3-dihydrosqualene mutase (cyclizing, tirucalla-7,24-dien-3beta-ol-forming).^[1] This enzyme catalyses the following chemical reaction

(3S)-2,3-epoxy-2,3-dihydrosqualene

\rightleftharpoons tirucalla-7,24-dien-3beta-ol

The product from Arabidopsis thaliana is tirucalla-7,24-dien-3beta-ol.

Notes and References

1. Morlacchi P, Wilson WK, Xiong Q, Bhaduri A, Sttivend D, Kolesnikova MD, Matsuda SP . Product profile of PEN3: the last unexamined oxidosqualene cyclase in Arabidopsis thaliana . Organic Letters . 11 . 12 . 2627–30 . June 2009 . 19445469 . 10.1021/ol9005745 .