Thyroglobulin domain explained

Thyroglobulin type-1 repeat is an evolutionary conserved protein domain.Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.

Human proteins containing this domain

CD74

IGFBP-4; IGFBP1; IGFBP2; IGFBP3; IGFBP4; IGFBP5; IGFBP6;NID1

NID2; SMOC1; SMOC2; SPOCK1; SPOCK2; SPOCK3; TACSTD1;TACSTD2

TG;

References

• Guncar G, Pungercic G, Klemencic I, Turk V, Turk D . Crystal structure of MHC class II-associated p41 Ii fragment bound to cathepsin L reveals the structural basis for differentiation between cathepsins L and S . The EMBO Journal . 18 . 4 . 793–803 . February 1999 . 10022822 . 1171172 . 10.1093/emboj/18.4.793 .
• Molina F, Bouanani M, Pau B, Granier C . Characterization of the type-1 repeat from thyroglobulin, a cysteine-rich module found in proteins from different families . European Journal of Biochemistry . 240 . 1 . 125–33 . August 1996 . 8797845 . 10.1111/j.1432-1033.1996.0125h.x . free .