Thiorphan Explained

Thiorphan is the active metabolite of the antidiarrheal racecadotril (acetorphan).^[1] It prevents the degradation of endogenous enkephalins by acting as an enkephalinase inhibitor.^{[1] [2]}

Notes and References

1. Spillantini MG, Geppetti P, Fanciullacci M, Michelacci S, Lecomte JM, Sicuteri F . In vivo 'enkephalinase' inhibition by acetorphan in human plasma and CSF . European Journal of Pharmacology . 125 . 1 . 147–50 . June 1986 . 3015640 . 10.1016/0014-2999(86)90094-4.
2. Drugs . 10804038 . 59 . 4 . Racecadotril . April 2000 . 829–35; discussion 836–7 . Matheson AJ, Noble S . 10.2165/00003495-200059040-00010. 245710392 .