Thiophanate-methyl explained

Thiophanate-methyl is an organic compound with the formula C₆H₄(NHC(S)NH(CO)OCH₃)₂. The compound is a colorless or white solid, although commercial samples are generally tan-colored. It is prepared from o-phenylenediamine. It is a widely used fungicide used on tree, vine, and root crops.^[1]

Methods for its analysis have received considerable attention.^{[2] [3] [4]} It is commonly used to treat botrytis bunch rot and gray mold caused by Botrytis cinerea strawberry in California. Thiophanate-methyl acts as a fungicide via its primary metabolite carbendazim.

Notes and References

1. Web site: Thiophanate-methyl . Environmental Protection Agency.
2. 10.1021/ac801557f. Toward a Generic Extraction Method for Simultaneous Determination of Pesticides, Mycotoxins, Plant Toxins, and Veterinary Drugs in Feed and Food Matrixes. 2008. Mol. Hans G. J.. Plaza-Bolaños. Patricia. Zomer. Paul. De Rijk. Theo C.. Stolker. Alida A. M.. Mulder. Patrick P. J.. Analytical Chemistry. 80. 24. 9450–9459. 19072261.
3. 10.1016/j.chroma.2011.01.034. Simultaneous determination of pesticides, biopesticides and mycotoxins in organic products applying a quick, easy, cheap, effective, rugged and safe extraction procedure and ultra-high performance liquid chromatography–tandem mass spectrometry. 2011. Romero-González. R.. Garrido Frenich. A.. Martínez Vidal. J.L.. Prestes. O.D.. Grio. S.L.. Journal of Chromatography A. 1218. 11. 1477–1485. 21292276.
4. 10.1016/j.chroma.2016.01.045. Multi-residue method for the determination of pesticides and pesticide metabolites in honeybees by liquid and gas chromatography coupled with tandem mass spectrometry—Honeybee poisoning incidents. 2016. Kiljanek. Tomasz. Niewiadowska. Alicja. Semeniuk. Stanisław. Gaweł. Marta. Borzęcka. Milena. Posyniak. Andrzej. Journal of Chromatography A. 1435. 100–114. 26830634.