Thiol sulfotransferase explained

Thiol sulfotransferase
Ec Number:	2.8.2.16
Cas Number:	70356-45-5

In enzymology, a thiol sulfotransferase is an enzyme that catalyzes the chemical reaction

3'-phosphoadenylyl sulfate + a thiol

\rightleftharpoons adenosine 3',5'-bisphosphate + an S-alkyl thiosulfate

Thus, the two substrates of this enzyme are 3'-phosphoadenylyl sulfate and thiol, whereas its two products are adenosine 3',5'-bisphosphate and S-alkyl thiosulfate.

This enzyme belongs to the family of transferases, specifically the sulfotransferases, which transfer sulfur-containing groups. The systematic name of this enzyme class is 3'-phosphoadenylyl-sulfate:thiol S-sulfotransferase. Other names in common use include phosphoadenylylsulfate-thiol sulfotransferase, PAPS sulfotransferase, and adenosine 3'-phosphate 5'-sulphatophosphate sulfotransferase.

References

• Schmidt A . The adenosine-5'-phosphosulfate sulfotransferase from spinach (Spinacea oleracea L.). Stabilization, partial purification, and properties . Planta . 130 . 3 . 257–63 . January 1976 . 24424637 . 10.1007/BF00387830 .
• Schmidt A, Christen U . 1979 . A PAPS-dependent sulfotransferase in Cyanophora paradoxa inhibited by 5'-AMP, 5'-ADP and APS . Z. Naturforsch. C: Biosci. . 34 . 222 - 228 .
• Tsang M . 1976 . L.-S. and Schiff, J.A. Studies of sulfate utilization by algae. 17 Reactions of the adenosine 5'-phosphosulfate (APS) sulfotransferase from Chlorella and studies of model reactions which explain the diversity of side products with thiols . Plant Cell Physiol. . 17 . 1209 - 1220 .