Thiol S-methyltransferase explained

thiol S-methyltransferase
Ec Number:	2.1.1.9
Cas Number:	9029-81-6
Go Code:	0018708

In enzymology, a thiol S-methyltransferase is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + a thiol

\rightleftharpoons S-adenosyl-L-homocysteine + a thioether

Thus, the two substrates of this enzyme are S-adenosyl methionine and thiol, whereas its two products are S-adenosylhomocysteine and thioether.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:thiol S-methyltransferase. Other names in common use include S-methyltransferase, thiol methyltransferase, and TMT. This enzyme participates in selenoamino acid metabolism.

References

• Borchardt RT, Cheng CF . 1978 . Purification and characterization of rat liver microsomal thiol methyltransferase . Biochim. Biophys. Acta . 522 . 340 - 53 . 623768 . 2 . 10.1016/0005-2744(78)90068-2.
• Bremer J . Greenberg DM . 1961 . Enzymic methylation of foreign sulfhydryl compounds . Biochim. Biophys. Acta . 46 . 2 . 217 - 224 . 10.1016/0006-3002(61)90746-6 .
• Weisiger RA, Jakoby WB . 1979 . Thiol S-methyltransferase from rat liver . Arch. Biochem. Biophys. . 196 . 631 - 7 . 485170 . 10.1016/0003-9861(79)90317-5 . 2 .