Thiamine transporter explained

Symbol:	Thia_YuaJ
Thia_YuaJ
Pfam:	PF09515
Pfam Clan:	CL0315
Interpro:	IPR012651
Opm Family:	134
Opm Protein:	3rlb

Members of this protein family have been assigned as thiamine transporters by a phylogenomic analysis of families of genes regulated by the THI element, a broadly conserved RNA secondary structure element through which thiamine pyrophosphate (TPP) levels can regulate transcription of many genes related to thiamine transport, salvage, and de novo biosynthesis. Species with this protein always lack the ThiBPQ ABC transporter. In some species (e.g. Streptococcus mutans and Streptococcus pyogenes), is the only THI-regulated gene. Evidence from Bacillus cereus indicates thiamine uptake is coupled to proton translocation.^{[1] [2]}

This family includes human solute transporters SLC19A1, SLC19A2 and SLC19A3.

Notes and References

1. Erkens GB, Slotboom DJ . Biochemical characterization of ThiT from Lactococcus lactis: a thiamin transporter with picomolar substrate binding affinity . Biochemistry . 49 . 14 . 3203–12 . April 2010 . 20218726 . 10.1021/bi100154r .
2. Eitinger T, Rodionov DA, Grote M, Schneider E . Canonical and ECF-type ATP-binding cassette importers in prokaryotes: diversity in modular organization and cellular functions . FEMS Microbiology Reviews . 35 . 1 . 3–67 . January 2011 . 20497229 . 10.1111/j.1574-6976.2010.00230.x . free .