Thebaine 6-O-demethylase explained

Thebaine 6-O-demethylase
Ec Number:	1.14.11.31

Thebaine 6-O-demethylase (T6ODM) is an enzyme with systematic name thebaine,2-oxoglutarate:oxygen oxidoreductase (6-O-demethylating).^[1] This enzyme catalyses the following chemical reaction

thebaine + 2-oxoglutarate + O₂

\rightleftharpoons neopinone + formaldehyde + succinate + CO₂

Thebaine 6-O-demethylase contains Fe²⁺.

Notes and References

1. Hagel JM, Facchini PJ . Dioxygenases catalyze the O-demethylation steps of morphine biosynthesis in opium poppy . Nature Chemical Biology . 6 . 4 . 273–5 . April 2010 . 20228795 . 10.1038/nchembio.317 .