Tetrahydroxynaphthalene reductase explained
| tetrahydroxynaphthalene reductase |
| Ec Number: | 1.1.1.252 |
| Cas Number: | 153702-05-7 |
| Go Code: | 0047039 |
In enzymology, a tetrahydroxynaphthalene reductase is an enzyme that catalyzes the chemical reaction
scytalone + NADP+
1,3,6,8-tetrahydroxynaphthalene + NADPH + H
+Thus, the two substrates of this enzyme are scytalone and NADP+, whereas its 3 products are 1,3,6,8-tetrahydroxynaphthalene, NADPH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is scytalone:NADP+ Delta5-oxidoreductase.
Structural studies
As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes,, and .
References
- Wheeler MH . Greenblatt GA . 1988 . The inhibition of melanin biosynthetic reactions in Pyricularia oryzae by compounds that prevent rice blast disease . Exp. Mycol. . 12 . 151 - 160 . 10.1016/0147-5975(88)90004-7 . 2 .
- Vidal-Cros A, Viviani F, Labesse G, Boccara M, Gaudry M . 1994 . Polyhydroxynaphthalene reductase involved in melanin biosynthesis in Magnaporthe grisea. Purification, cDNA cloning and sequencing . Eur. J. Biochem. . 219 . 985 - 92 . 8112349 . 10.1111/j.1432-1033.1994.tb18581.x . 3 . free .
- Thompson JE, Basarab GS, Andersson A, Lindqvist Y, Jordan DB . 1997 . Trihydroxynaphthalene reductase from Magnaporthe grisea: realization of an active center inhibitor and elucidation of the kinetic mechanism . Biochemistry . 36 . 1852 - 60 . 9048570 . 10.1021/bi962355u . 7 .
