Tetrachlorodecaoxide Explained

"Tetrachlorodecaoxide" (TCDO) is a chlorite-containing substance with claimed immunomodulatory, macrophage-activating properties.[1] WF10 (Macrokine, Immunokine, Oxoferin) is an aqueous solution of tetrachlorodecaoxide designed for intravenous injection. Tetrachlorodecaoxide/WF10 were originally developed by Oxo Chemie.[2] The chemical formula is given as Cl4H2O114-.[3] [4] This incomplete formula shows a mixture of chlorite ion, water, and molecular oxygen: "Cl4H2O114-" = 4ClO2− + H2O + O2. Oxoferin was found to be equivalent with aqueous sodium chlorite.[5]

Tetrachlorodecaoxide / WF10 is used in the management of radiation cystitis,[6] is effective in the treatment of diabetic foot ulcers,[7] and is used in wound healing, where the mechanism of action is activation of the macrophage system, and increasing the partial pressure of oxygen in the wound.[8]

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Notes and References

  1. Maraprygsavan P, Mongkolsuk J, Arnhold J, Kuehne FW . The chlorite-based drug WF10 constantly reduces hemoglobin A1c values and improves glucose control in diabetes patients with severe foot syndrome . Journal of Clinical & Translational Endocrinology . 4 . 53–58 . June 2016 . 29159131 . 5680448 . 10.1016/j.jcte.2016.05.001 .
  2. Web site: About Us . https://web.archive.org/web/20161220173657/http://oxothai.com/about-us/ . 2016-12-20 . OXO Chemie (Thai) . 2016-12-20.
  3. Web site: Tetrachlorodecaoxide - Cl4H2O11-4 . PubChem . U.S. National Library of Medicine . 2016-12-20.
  4. Web site: WF10 . Drugprofiles.informa.com. 2016-12-20.
  5. Habermann E, Müller B . Oxoferin und Natriumchlorit — Ein Vergleich . Oxoferin and sodium chlorite — a comparison . Klinische Wochenschrift . 67 . 20–25 . Jan 1989 . 1 . 2921839 . 10.1007/bf01736530 . de.
  6. Smit SG, Heyns CF . 29208541 . Management of radiation cystitis . Nature Reviews. Urology . 7 . 4 . 206–14 . April 2010 . 20212517 . 10.1038/nrurol.2010.23 . 10019.1/14211 . free .
  7. Yingsakmongkol N . Clinical outcomes of WF10 adjunct to standard treatment of diabetic foot ulcers . Journal of Wound Care . 22 . 3 . 130–2, 134–6 . March 2013 . 23665731 . 10.12968/jowc.2013.22.3.130 .
  8. Parikh R, Bakhshi G, Naik M, Gaikwad B, Jadhav K, Tayade M . The Efficacy and Safety of Tetrachlorodecaoxide in Comparison with Super-oxidised Solution in Wound Healing . Archives of Plastic Surgery . 43 . 5 . 395–401 . September 2016 . 27689045 . 5040840 . 10.5999/aps.2016.43.5.395 .

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