| testosterone 17-beta-dehydrogenase (NAD+) | |
| Ec Number: | 1.1.1.63 |
| Cas Number: | 9028-62-0 |
| Go Code: | 0050327 |
| testosterone 17-beta-dehydrogenase (NADP+) | |
| Ec Number: | 1.1.1.64 |
| Cas Number: | 9028-63-1 |
| Go Code: | 0047045 |
In enzymology, a testosterone 17beta-dehydrogenase is an enzyme that catalyzes the chemical reaction between testosterone and androst-4-ene-3,17-dione. This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor.
The systematic name of this enzyme class is 17beta-hydroxysteroid:NAD+ 17-oxidoreductase. Other names in common use include 17-ketoreductase and 17beta-HSD. This enzyme participates in androgen and estrogen metabolism.
There are two variants of the enzyme, one that uses NAD+ as a substrate, and one that uses NADP+ as acceptor.
See main article: 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+).
This variant of testosterone 17beta-dehydrogenase catalyzes the reaction
testosterone + NAD+
\rightleftharpoons
Thus, the two substrates of this enzyme are testosterone and NAD+, whereas its 3 products are androst-4-ene-3,17-dione, NADH, and H+.
See main article: Testosterone 17b-dehydrogenase (NADP+). This variant of testosterone 17beta-dehydrogenase catalyzes the reaction
testosterone + NADP+
\rightleftharpoons
Thus, the two substrates of this enzyme are testosterone and NADP+, whereas its 3 products are androst-4-ene-3,17-dione, NADPH, and H+.