Terpentedienyl-diphosphate synthase explained

Terpentedienyl-diphosphate synthase
Ec Number:	5.5.1.15

Terpentedienyl-diphosphate synthase (terpentedienol diphosphate synthase, Cyc1, clerodadienyl diphosphate synthase) is an enzyme with systematic name terpentedienyl-diphosphate lyase (decyclizing).^{[1] [2] [3]} This enzyme catalyses the following chemical reaction

geranylgeranyl diphosphate

\rightleftharpoons terpentedienyl diphosphate

This enzyme requires Mg²⁺.

Notes and References

1. Dairi T, Hamano Y, Kuzuyama T, Itoh N, Furihata K, Seto H . Eubacterial diterpene cyclase genes essential for production of the isoprenoid antibiotic terpentecin . Journal of Bacteriology . 183 . 20 . 6085–94 . October 2001 . 11567009 . 99688 . 10.1128/jb.183.20.6085-6094.2001 .
2. Hamano Y, Kuzuyama T, Itoh N, Furihata K, Seto H, Dairi T . Functional analysis of eubacterial diterpene cyclases responsible for biosynthesis of a diterpene antibiotic, terpentecin . The Journal of Biological Chemistry . 277 . 40 . 37098–104 . October 2002 . 12138123 . 10.1074/jbc.m206382200 . free .
3. Eguchi T, Dekishima Y, Hamano Y, Dairi T, Seto H, Kakinuma K . A new approach for the investigation of isoprenoid biosynthesis featuring pathway switching, deuterium hyperlabeling, and 1H NMR spectroscopy. The reaction mechanism of a novel streptomyces diterpene cyclase . The Journal of Organic Chemistry . 68 . 14 . 5433–8 . July 2003 . 12839434 . 10.1021/jo026728a .