Terephthalate 1,2-cis-dihydrodiol dehydrogenase explained

terephthalate 1,2-cis-dihydrodiol dehydrogenase
Ec Number:	1.3.1.61
Go Code:	0018514

In enzymology, a terephthalate 1,2-cis-dihydrodiol dehydrogenase is an enzyme that catalyzes the chemical reaction:

cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,4-dicarboxylate + NAD⁺

\rightleftharpoons 3,4-dihydroxybenzoate + CO₂ + NADH

Thus, the two substrates of this enzyme are cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,4-dicarboxylate and NAD⁺, whereas its 3 products are 3,4-dihydroxybenzoate, CO₂, and NADH.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,4-dicarboxylate:NAD+ oxidoreductase (decarboxylating). This enzyme participates in 2,4-dichlorobenzoate degradation.

References

• Wang YZ, Zhou Y, Zylstra GJ . 1995 . Molecular analysis of isophthalate and terephthalate degradation by Comamonas testosteroni YZW-D . Environ. Health Perspect. . 103 . Suppl. 5 . 9 - 12 . 8565920 . 1519302 .