Taspine Explained

Taspine is an alkaloid which acts as a potent acetylcholinesterase inhibitor and cicatrizant. It is found in various plants including Magnolia x soulangeana[1] and Croton lechleri.[2]

The first total synthesis was reported by T. Ross Kelly and Roger L. Xie in 1998.[3]

Notes and References

  1. Journal of Natural Products . 2006 . 69 . 1341–1346 . 10.1021/np060268p . 16989531 . Rollinger . JM . Schuster . D . Baier . E . Ellmerer . EP . Langer . T . Stuppner . H . Taspine: Bioactivity-guided isolation and molecular ligand-target insight of a potent acetylcholinesterase inhibitor from Magnolia x soulangiana . 9 . 3526713.
  2. Vaisberg . A. . Milla . M. . Planas . M. . Cordova . J. . De Agusti . E. . Ferreyra . R. . Mustiga . M. . Carlin . L. . Hammond . G. . 10.1055/s-2006-961907 . Taspine is the Cicatrizant Principle in Sangre de Grado Extracted from Croton lechleri. Planta Medica . 55 . 2 . 140–143 . 2007 . 2748730 . 260251205 .
  3. Kelly. T. Ross. Xie. Roger L.. Total Synthesis of Taspine. The Journal of Organic Chemistry. October 1998. 63. 22. 8045–8048. 10.1021/jo981099j.

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