Tampramine Explained

Tampramine (AHR-9,377) is a tricyclic antidepressant (TCA) which was developed in the 1980s but was never marketed.[1] Despite being a TCA, it acts as a selective norepinephrine reuptake inhibitor and has negligible affinity for adrenergic, histaminergic, and muscarinic receptors.[2] It was found to be effective in the forced swim test (FST) model of depression in animal studies but is not known to have ever been trialed in humans.[1]

See also

Notes and References

  1. O'Donnell JM, Seiden LS . Effect of the experimental antidepressant AHR-9377 on performance during differential reinforcement of low response rate . Psychopharmacology . 87 . 3 . 283–5 . 1985 . 3936083 . 10.1007/BF00432708. 20677730 .
  2. Kinnier WJ, Tabor RD, Norrell LY . Neurochemical properties of AHR-9377: a novel inhibitor of norepinephrine reuptake . . 33 . 19 . 3001–5 . October 1984 . 6548381 . 10.1016/0006-2952(84)90600-2.

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Tampramine".

Except where otherwise indicated, Everything.Explained.Today is © Copyright 2009-2025, A B Cryer, All Rights Reserved. Cookie policy.