Talsupram Explained

Talsupram (Lu 5-005 or Lu 5-003^[1]) is a selective norepinephrine reuptake inhibitor (NRI) which was investigated as an antidepressant in the 1960s and 1970s but was never marketed.^{[2] [3] [4]} Along with talopram, it is structurally related to the selective serotonin reuptake inhibitor (SSRI) citalopram.^[5]

See also

• Talopram

Notes and References

1. Carlsson A, Fuxe K, Hamberger B, Malmfors T . Effect of a new series of bicyclic compounds with potential thymoleptic properties on the reserpine-resistant uptake mechanism of central and peripheral monoamine neurones in vivo and in vitro . British Journal of Pharmacology . 36 . 1 . 18–28 . May 1969 . 5768100 . 1703539 . 10.1111/j.1476-5381.1969.tb08299.x . free . 6895508396 .
2. Pawłowski L, Mazela H . Effects of antidepressant drugs, selective noradrenaline-or 5-hydroxytryptamine uptake inhibitors, on apomorphine-induced hypothermia in mice . Psychopharmacology . 88 . 2 . 240–246 . June 1986 . 3006113 . 10.1007/BF00652248 . 1732297 . 5653283278 .
3. McConathy J, Owens MJ, Kilts CD, Malveaux EJ, Camp VM, Votaw JR, Nemeroff CB, Goodman MM . Synthesis and biological evaluation of [11C]talopram and [11C]talsupram: candidate PET ligands for the norepinephrine transporter . Nuclear Medicine and Biology . 31 . 6 . 705–718 . August 2004 . 15246361 . 10.1016/j.nucmedbio.2003.05.001 .
4. Kelliher P, Kelly JP, Leonard BE, Sánchez C . Effects of acute and chronic administration of selective monoamine re-uptake inhibitors in the rat forced swim test . Psychoneuroendocrinology . 28 . 3 . 332–347 . April 2003 . 12573300 . 10.1016/S0306-4530(02)00026-4 . 23452713 .
5. Web site: The SSRI Issues . DOC . healyprozac.com . January 3, 2024.