Talopram Explained

Talopram (Lu 3-010),^[1] also known as phthalapromine, is a selective norepinephrine reuptake inhibitor (NRI) which was researched for the management of depression in the 1960s and 1970s but was never commercialized. Along with talsupram, talopram is structurally related to the selective serotonin reuptake inhibitor (SSRI) citalopram,^[2] as well as to melitracen:^[3]

Synthesis

An unexpected/fortuitous rearrangement product in the synthesis of litracen is what led to talopram.^{[3] [4]}

See also

• Talsupram (tasulopram)
• Amedalin
• Daledalin
• , 1969 (#15).
• Original literature^[5]
• Prindamine (21489-22-5)^[6]

Notes and References

1. Carlsson A, Fuxe K, Hamberger B, Malmfors T . Effect of a new series of bicyclic compounds with potential thymoleptic properties on the reserpine-resistant uptake mechanism of central and peripheral monoamine neurones in vivo and in vitro . British Journal of Pharmacology . 36 . 1 . 18–28 . May 1969 . 5768100 . 1703539 . 10.1111/j.1476-5381.1969.tb08299.x .
2. Eildal JN, Andersen J, Kristensen AS, Jørgensen AM, Bang-Andersen B, Jørgensen M, Strømgaard K . From the selective serotonin transporter inhibitor citalopram to the selective norepinephrine transporter inhibitor talopram: synthesis and structure-activity relationship studies . Journal of Medicinal Chemistry . 51 . 10 . 3045–8 . May 2008 . 18429609 . 10.1021/jm701602g .
3. Book: Healy, David . The History of the SSRIs . http://www.healyprozac.com/Book/Introduction.pdf . Let Them Eat Prozac . vanc .
4. GB. 939856. 1963-10-16. Aminopropylidene-dihydroanthracenes. Kefalas AS. Holm. Torkil.
5. Petersen PV, Lassen N, Hansen V, Huld T, Hjortkjaer J, Holmblad J, Nielsen IM, Nymark M, Pedersen V, Jorgensen A, Hougs W . 6 . Pharmacological studies of a new series of bicyclic thymoleptics . Acta Pharmacologica et Toxicologica . 24 . 2 . 121–33 . 2009 . 4165059 . 10.1111/j.1600-0773.1966.tb00375.x .
6. Web site: Prindamine . ChemicalBook .