Talopeptin Explained

Talopeptin is a chemical compound derived from cultures of Streptomyces. It is a known reversible inhibitor of thermolysin^[1] and is expected to inhibit other metalloproteinases.^{[2] [3]} Chemically, talopeptin differs from its closely related peptidase inhibitor phosphoramidon by a single stereocenter.

External links

• The MEROPS online database for peptidases and their inhibitors: Talopeptin

Notes and References

1. Kitagishi, Keiko . Hiromi, Keitaro . Inhibitory spectrum of talopeptin (MKI), a specific inhibitor of thermolysin . Agricultural and Biological Chemistry . 1984 . 48 . 5 . 1287–91 . 10.1271/bbb1961.48.1287. free .
2. Fukuhara, Kenichi . Murao, Sawao . Nozawa, Tsunenori . Hatano, Masahiro . Structural elucidation of talopeptin (MK-I), a novel metallo proteinase inhibitor produced by Streptomyces mozunensis MK-23 . Tetrahedron Letters . 1982 . 23 . 22 . 2319–22. 10.1016/S0040-4039(00)87331-1.
3. Kitagishi, Keiko . Hiromi, Keitaro . Oda, Kohei . Murao, Sawao . Equilibrium study on the binding between thermolysin and Streptomyces metalloprotease inhibitor, talopeptin (MKI) . Journal of Biochemistry . 1983 . 93 . 1 . 47–53 . 6341369. 10.1093/oxfordjournals.jbchem.a134176 .