TRNA (guanine10-N2)-methyltransferase explained

TRNA (guanine^10-N^2)-methyltransferase
Ec Number:	2.1.1.214

TRNA (guanine¹⁰-N²)-methyltransferase ((m2G10) methyltransferase, Trm11-Trm112 complex) is an enzyme with systematic name S-adenosyl-L-methionine:tRNA (guanine¹⁰-N²)-methyltransferase.^[1] This enzyme catalyses the following chemical reaction

S-adenosyl-L-methionine + guanine¹⁰ in tRNA

\rightleftharpoons S-adenosyl-L-homocysteine + N²-methylguanine¹⁰ in tRNA

tRNA (guanine¹⁰-N²)-methyltransferase from yeast does not catalyse the methylation from N²-methylguanine¹⁰ to N²-dimethylguanine¹⁰ in tRNA.

Notes and References

1. Purushothaman SK, Bujnicki JM, Grosjean H, Lapeyre B . Trm11p and Trm112p are both required for the formation of 2-methylguanosine at position 10 in yeast tRNA . Molecular and Cellular Biology . 25 . 11 . 4359–70 . June 2005 . 15899842 . 1140639 . 10.1128/MCB.25.11.4359-4370.2005 .