TRNA (cytosine34-C5)-methyltransferase explained

TRNA (cytosine34-C5)-methyltransferase
Ec Number:2.1.1.203

TRNA (cytosine34-C5)-methyltransferase (hTrm4 Mtase, hTrm4 methyltransferase, hTrm4 (gene), tRNA:m5C-methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:tRNA (cytosine34-C5)-methyltransferase.[1] This enzyme catalyses the following chemical reaction

S-adenosyl-L-methionine + cytosine34 in tRNA precursor

\rightleftharpoons

S-adenosyl-L-homocysteine + 5-methylcytosine34 in tRNA precursor

The human enzyme is specific for C5-methylation of cytosine34 in tRNA precursors.

Notes and References

  1. Brzezicha B, Schmidt M, Makalowska I, Jarmolowski A, Pienkowska J, Szweykowska-Kulinska Z . Identification of human tRNA:m5C methyltransferase catalysing intron-dependent m5C formation in the first position of the anticodon of the pre-tRNA Leu (CAA) . Nucleic Acids Research . 34 . 20 . 6034–43 . 2006 . 17071714 . 1635329 . 10.1093/nar/gkl765 .

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "TRNA (cytosine34-C5)-methyltransferase".

Except where otherwise indicated, Everything.Explained.Today is © Copyright 2009-2024, A B Cryer, All Rights Reserved. Cookie policy.