TRNA (adenine9-N1)-methyltransferase explained

TRNA (adenine^9-N^1)-methyltransferase
Ec Number:	2.1.1.218

TRNA (adenine⁹-N¹)-methyltransferase (Trm10p, tRNA(m1G9/m1A9)-methyltransferase, tRNA(m1G9/m1A9)MTase, TK0422p (gene), tRNA m1A9-methyltransferase, tRNA m1A9 Mtase) is an enzyme with systematic name S-adenosyl-L-methionine:tRNA (adenine⁹-N¹)-methyltransferase.^[1] This enzyme catalyses the following chemical reaction

S-adenosyl-L-methionine + adenine⁹ in tRNA

\rightleftharpoons S-adenosyl-L-homocysteine + N¹-methyladenine⁹ in tRNA

The enzyme from Sulfolobus acidocaldarius specifically methylates adenine⁹ in tRNA.

Notes and References

1. Kempenaers M, Roovers M, Oudjama Y, Tkaczuk KL, Bujnicki JM, Droogmans L . New archaeal methyltransferases forming 1-methyladenosine or 1-methyladenosine and 1-methylguanosine at position 9 of tRNA . Nucleic Acids Research . 38 . 19 . 6533–43 . October 2010 . 20525789 . 2965216 . 10.1093/nar/gkq451 .