TRNA (adenine22-N1)-methyltransferase explained

TRNA (adenine^22-N^1)-methyltransferase
Ec Number:	2.1.1.217

TRNA (adenine²²-N¹)-methyltransferase (TrmK, YqfN, Sp1610 (gene), tRNA: m1A22 methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:tRNA (adenine²²-N¹)-methyltransferase.^{[1] [2]} This enzyme catalyses the following chemical reaction

S-adenosyl-L-methionine + adenine²² in tRNA

\rightleftharpoons S-adenosyl-L-homocysteine + N¹-methyladenine²² in tRNA

The enzyme specifically methylates adenine²² in tRNA.

Notes and References

1. Ta HM, Kim KK . Crystal structure of Streptococcus pneumoniae Sp1610, a putative tRNA methyltransferase, in complex with S-adenosyl-L-methionine . Protein Science . 19 . 3 . 617–24 . March 2010 . 20052680 . 2866285 . 10.1002/pro.319 .
2. Roovers M, Kaminska KH, Tkaczuk KL, Gigot D, Droogmans L, Bujnicki JM . The YqfN protein of Bacillus subtilis is the tRNA: m1A22 methyltransferase (TrmK) . Nucleic Acids Research . 36 . 10 . 3252–62 . June 2008 . 18420655 . 2425500 . 10.1093/nar/gkn169 .