| tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase | |
| Ec Number: | 2.1.1.61 |
| Cas Number: | 39391-17-8 |
| Go Code: | 0004808 |
In enzymology, a tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase is an enzyme that catalyzes the chemical reaction
S-adenosyl-L-methionine + tRNA
\rightleftharpoons
Thus, the two substrates of this enzyme are S-adenosyl methionine and tRNA, whereas its two products are S-adenosylhomocysteine and tRNA containing 5-methylaminomethyl-2-thiouridylic acid.
This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:tRNA (5-methylaminomethyl-2-thio-uridylate)-methyltransferase. Other names in common use include transfer ribonucleate 5-methylaminomethyl-2-thiouridylate, 5-methyltransferase, and tRNA 5-methylaminomethyl-2-thiouridylate 5'-methyltransferase.
As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes,,, and .