TRNASer (uridine44-2'-O)-methyltransferase explained

TRNASer (uridine^44-2'-O)-methyltransferase
Ec Number:	2.1.1.211

TRNASer (uridine⁴⁴-2'-O)-methyltransferase (TRM⁴⁴) is an enzyme with systematic name S-adenosyl-L-methionine:tRNASer (uridine⁴⁴-2'-O)-methyltransferase.^[1] This enzyme catalyses the following chemical reaction

\rightleftharpoons S-adenosyl-L-homocysteine + 2'-O-methyluridine⁴⁴ in tRNASer

The 2'-O-methylation of uridine⁴⁴ contributes to stability of tRNASer(CGA).

Notes and References

1. Kotelawala L, Grayhack EJ, Phizicky EM . Identification of yeast tRNA Um(44) 2'-O-methyltransferase (Trm44) and demonstration of a Trm44 role in sustaining levels of specific tRNA(Ser) species . RNA . 14 . 1 . 158–69 . January 2008 . 18025252 . 2151035 . 10.1261/rna.811008 .