TRNA-uridine aminocarboxypropyltransferase explained

tRNA-uridine aminocarboxypropyltransferase
Ec Number:	2.5.1.25
Go Code:	0016432

In enzymology, a tRNA-uridine aminocarboxypropyltransferase is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + tRNA uridine

\rightleftharpoons 5'-methylthioadenosine + tRNA 3-(3-amino-3-carboxypropyl)-uridine

Thus, the two substrates of this enzyme are S-adenosyl-L-methionine and tRNA uridine, whereas its two products are 5'-methylthioadenosine and tRNA 3-(3-amino-3-carboxypropyl)-uridine.

This enzyme belongs to the family of transferases, specifically those transferring aryl or alkyl groups other than methyl groups. The systematic name of this enzyme class is S-adenosyl-L-methionine:tRNA-uridine 3-(3-amino-3-carboxypropyl)transferase.

References

• Nishimura S, Taya Y, Kuchino Y, Oashi Z . 1974 . Enzymatic synthesis of 3-(3-amino-3-carboxypropyl)uridine in Escherichia coli phenylalanine transfer RNA: transfer of the 3-amino-acid-3-carboxypropyl group from S-adenosylmethionine . Biochem. Biophys. Res. Commun. . 57 . 702 - 8 . 4597321 . 3 . 10.1016/0006-291X(74)90603-2 .