TRNA-queuosine beta-mannosyltransferase explained

tRNA-queuosine beta-mannosyltransferase
Ec Number:	2.4.1.110
Cas Number:	9055-06-5
Go Code:	0016438

In enzymology, a tRNA-queuosine beta-mannosyltransferase is an enzyme that catalyzes the chemical reaction

GDP-mannose + tRNAAsp-queuosine

\rightleftharpoons GDP + tRNAAsp-O-5"-beta-D-mannosylqueuosine

Thus, the two substrates of this enzyme are GDP-mannose and tRNAAsp-queuosine, whereas its two products are GDP and tRNAAsp-O-5-beta-D-mannosylqueuosine.

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is GDP-mannose:tRNAAsp-queuosine O-5"-beta-D-mannosyltransferase.

References

• Okada N, Nishimura S . 1977 . Enzymatic synthesis of Q nucleoside containing mannose in the anticodon of tRNA: isolation of a novel mannosyltransferase from a cell-free extract of rat liver . Nucleic Acids Res. . 4 . 2931 - 8 . 20603 . 10.1093/nar/4.8.2931 . 8 . 342620 .