TRNA-guanine15 transglycosylase explained

TRNA-guanine15 transglycosylase
Ec Number:2.4.2.48

TRNA-guanine15 transglycosylase (tRNA transglycosylase, transfer ribonucleate glycosyltransferase, tRNA guanine15 transglycosidase, TGT, transfer ribonucleic acid guanine15 transglycosylase) is an enzyme with systematic name tRNA-guanine15:7-cyano-7-carbaguanine tRNA-D-ribosyltransferase.[1] This enzyme catalyses the following chemical reaction

guanine15 in tRNA + 7-cyano-7-carbaguanine

\rightleftharpoons

7-cyano-7-carbaguanine15 in tRNA + guanine

Archaeal tRNAs contain the modified nucleoside archaeosine at position 15.

Notes and References

  1. Bai Y, Fox DT, Lacy JA, Van Lanen SG, Iwata-Reuyl D . Hypermodification of tRNA in Thermophilic archaea. Cloning, overexpression, and characterization of tRNA-guanine transglycosylase from Methanococcus jannaschii . The Journal of Biological Chemistry . 275 . 37 . 28731–8 . September 2000 . 10862614 . 10.1074/jbc.M002174200 . free .

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