TRNA-dihydrouridine20a/20b synthase (NAD(P)+) explained

TRNA-dihydrouridine20a/20b synthase (NAD(P)+)
Ec Number:1.3.1.90

TRNA-dihydrouridine20a/20b synthase (NAD(P)+) (Dus4p) is an enzyme with systematic name tRNA-5,6-dihydrouracil20a/20b:NAD(P)+ oxidoreductase.[1] This enzyme catalyses the following chemical reaction

(1) 5,6-dihydrouracil20a in tRNA + NAD(P)+

\rightleftharpoons

uracil20a in tRNA + NAD(P)H + H+

(2) 5,6-dihydrouracil20b in tRNA + NAD(P)+

\rightleftharpoons

uracil20b in tRNA + NAD(P)H + H+

A flavoenzyme. The enzyme specifically modifies uracil20a and uracil20b in tRNA.

Notes and References

  1. Xing F, Hiley SL, Hughes TR, Phizicky EM . The specificities of four yeast dihydrouridine synthases for cytoplasmic tRNAs . The Journal of Biological Chemistry . 279 . 17 . 17850–60 . April 2004 . 14970222 . 10.1074/jbc.M401221200 . free .

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