Synthetic ribosome explained

Synthetic ribosomes are artificial small-molecules that can synthesize peptides in a sequence-specific matter.[1]

David Alan Leigh's lab built synthetic ribosome using a chemical structure based on a rotaxane.[2]

The Cédric Orelle research group created ribosomes with tethered and inseparable subunits (or Ribo-T).[3]

Notes and References

  1. Synthetic ribosomes . 3609622 . 23324614 . 10.4161/bioe.23640 . 4 . 2 . 2013 . Bioengineered . 63–4 . Sleator . RD.
  2. Sequence-specific peptide synthesis by an artificial small-molecule machine. 23307739 . 10.1126/science.1229753 . 339 . 6116 . Science . 189–93 . Lewandowski . B . De Bo . G . Ward . JW . Papmeyer . M . Kuschel . S . Aldegunde . MJ . Gramlich . PM . Heckmann . D . Goldup . SM . D'Souza . DM . Fernandes . AE . Leigh . DA. 2013 .
  3. Protein synthesis by ribosomes with tethered subunits . 10.1038/nature14862 . 26222032 . 524 . 7563 . Nature . 119–124. 2015 . Orelle . Cédric . Carlson . Erik D. . Szal . Teresa . Florin . Tanja . Jewett . Michael C. . Mankin . Alexander S. .

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