Beginning with three synods convened between 264 and 269 in the matter of Paul of Samosata, more than thirty councils were held in Antioch in ancient times. Most of these dealt with phases of the Arian and of the Christological controversies. For example, the Catholic Encyclopedia article on Paul of Samosata states:
The most celebrated convened in the summer of 341 at the dedication of the Domus Aurea, and is therefore called or dedication council. Nearly a hundred Eastern bishops were present, but the bishop of Rome was not represented. The emperor Constantius II attended in person.
The first Synod of Antioch, which took place between 264 and 269, was one of the early significant ecclesiastical councils in the Christian Church. This synod was primarily convened to address the teachings of Paul of Samosata, who was the Bishop of Antioch.
Paul of Samosata had introduced a doctrine that was considered heretical by the mainstream Church, particularly concerning the nature of Christ and the Holy Trinity. His teachings were seen as a form of Monarchianism, which emphasized the indivisibility of God at the expense of the distinct persons of the Trinity.
The synod ultimately condemned Paul’s teachings and deposed him from his position as Bishop. It is also noted that the council rejected the term homoousios—meaning “of the same substance”—but this was in the specific context of Paul’s usage, which implied a division of substance between the Father and the Son, rather than the orthodox interpretation of the Trinity as three distinct persons of one substance.
This synod was significant as it set a precedent for the Church’s handling of heresy and laid the groundwork for future ecumenical councils, which would further define Christian doctrine, such as the First Council of Nicaea in 325.
The council approved three creeds.[1] The “Second Creed of Antioch, often known both in the ancient and the modern world as the 'Dedication' Creed, was the Council's most important result.”[2] (RH, 285-6) Its “chief bête noire [the thing that it particularly dislikes] is Sabellianism, the denial of a distinction between the three within the Godhead.”[3] (RH, 287)
Furthermore, the Creed “deliberately excludes the kind of Arianism professed by Arius and among his followers by Eusebius of Nicomedia/Constantinople.”[4] (RH, 290) It “does anathematize doctrines associated … with Arius.”[5] (LA, 120) For example, the Creed anathematizes all who say: “that either time or occasion or age exists or did exist before the Son was begotten”[6] (RH, 286)
The so-called "fourth formula"[7] could be ascribed to a continuation of this synod or to a subsequent but distinct assembly of the same year. “It is widely accepted that this creed was intended to function as a reconciling formula obnoxious to nobody and capable of being accepted by all.”[8] (RH, 291)
All four of these formulae avoid the term homoousios which was accepted by the First Council of Nicaea (Nicaea I). At the time of the Dedication Council, nobody mentioned the Nicene Creed or the term homoousios. “During the years 326–50 the term homoousios is rarely if ever mentioned.”[9] (LA, 431) “Even Athanasius for about twenty years after Nicaea is strangely silent about this adjective (homoousios) which had been formally adopted into the creed of the Church in 325.”[10] (RH, 58-59) Athanasius brought the term back into the Controversy only in the mid 350s.
“Many scholars have noticed the affinities between this creed and the kind of doctrine which Eusebius of Caesarea taught … before the Arian Controversy came into the open. The ancestors of this creed are Origen, Eusebius of Caesarea and Asterius.”[11] (RH, 290) For a further discussion, see the Dedication Creed under Arian Creeds.
The twenty-five canons adopted regulate the so-called metropolitan constitution of the church. Ecclesiastical power is vested chiefly in the metropolitan (later called archbishop), and the biannual provincial synod (see Nicaea I, canon 5.), which he summons and over which he presides. Consequently, the powers of country bishops (chorepiscopi) are curtailed, and direct recourse to the emperor is forbidden. The sentence of one judicatory is to be respected by other judicatories of equal rank; re-trial may take place only before that authority to whom appeal regularly lies.[12] Without due invitation, a bishop may not ordain, or in any other way interfere with affairs lying outside his proper territory; nor may he appoint his own successor. Penalties are set on the refusal to celebrate Easter in accordance with the Nicaea I decree, as well as on leaving a church before the service of the Eucharist is completed.
The numerous objections made by scholars in past centuries about the canons ascribed to this council have been elaborately stated and probably refuted by Hefele. The canons formed part of the Codex canonum used at Chalcedon in 451 and are found in later Eastern and Western collections of canons.