Suxibuzone Explained

Verifiedfields:changed
Watchedfields:changed
Verifiedrevid:408916457
Iupac Name:4-[[4-butyl-3,5-dioxo-1,2-di(phenyl)pyrazolidin-4-yl]methoxy]-4-oxobutanoic acid
Cas Number:27470-51-5
Atc Prefix:M02
Atc Suffix:AA22
Pubchem:5362
Unii:86TDZ5WP2B
Kegg:D01289
Chembl:1414320
Chemspiderid:5169
Smiles:O=C(O)CCC(=O)OCC2(C(=O)N(c1ccccc1)N(C2=O)c3ccccc3)CCCC
Stdinchi:1S/C24H26N2O6/c1-2-3-16-24(17-32-21(29)15-14-20(27)28)22(30)25(18-10-6-4-7-11-18)26(23(24)31)19-12-8-5-9-13-19/h4-13H,2-3,14-17H2,1H3,(H,27,28)
Stdinchikey:ONWXNHPOAGOMTG-UHFFFAOYSA-N
C:24
H:26
N:2
O:6

Suxibuzone is an analgesic used for joint and muscular pain. It is a prodrug of the non-steroidal anti-inflammatory drug (NSAID) phenylbutazone,[1] and is commonly used in horses.[2]

Notes and References

  1. Yasuda Y, Shindo T, Mitani N, Ishida N, Oono F, Kageyama T. 1982. Comparison of the absorption, excretion, and metabolism of suxibuzone and phenylbutazone in humans. Journal of Pharmaceutical Sciences. 71. 5. 565–72. 7097505. 10.1002/jps.2600710521.
  2. Sabaté D, Homedes J, Salichs M, Sust M, Monreal L. 2009. Multicentre, controlled, randomised and blinded field study comparing efficacy of suxibuzone and phenylbutazone in lame horses. Equine Veterinary Journal. 41. 7. 700–5. 19927590. 10.2746/042516409X464807.