Suprofen Explained

Suprofen is a nonsteroidal anti-inflammatory drug (NSAID) developed by Janssen Pharmaceutica[1] that was marketed as 1% eye drops under the trade name Profenal.

Uses

Suprofen was originally used as tablet, but oral uses have been discontinued due to renal effects.[2] It was subsequently used exclusively as a topical ophthalmic solution, typically to prevent miosis during and after ophthalmic surgery.[3] This application has been discontinued as well, at least in the US.[4]

Notes and References

  1. DE . 2353357 . Antiphlogistic aroyl-substituted phenylacetic acid derivatives . Janssen PA, Van Daele GH, Boey JM . 1974 .
  2. Book: Nies AS . Renal Effects of Nonsteroidal Anti-Inflammatory Drugs . Basis for Variability of Response to Anti-Rheumatic Drugs . Agents and Actions. Supplements . 24 . 95–106 . 1988 . 3142236 . 10.1007/978-3-0348-9160-8_9 . 2024-02-09 . 978-3-0348-9931-4 .
  3. Web site: Pharmacy Compounding . https://web.archive.org/web/20090101224625/https://www.fda.gov/ora/compliance_ref/cpg/cpgdrg/cpg460-200.html . 1 January 2009 . Guidance for FDA Staff and Industry Compliance Policy Guides Manual . U.S. Food and Drug Administration .
  4. Web site: Suprofen ophthalmic . Drugs.com . 2018-01-23 . 2021-09-09 . https://web.archive.org/web/20210909164216/https://www.drugs.com/mtm/suprofen-ophthalmic.html . dead .

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