Superoxide reductase explained
| superoxide reductase |
| Ec Number: | 1.15.1.2 |
| Cas Number: | 250679-67-5 |
| Go Code: | 0050605 |
Superoxide reductase is an enzyme that catalyzes the conversion of highly reactive and toxic superoxide (O2−) into less toxic hydrogen peroxide (H2O2):
reduced rubredoxin + O2− + 2 H+
rubredoxin + H
2O
2Fe2+ + O2− + 2 H+
Fe
3++ H
2O
2Hydrogen peroxide in turn is reduced to water by rubrerythrin. The 3 substrates of this enzyme are reduced rubredoxin, superoxide, and H+, whereas its two products are rubredoxin and H2O2.
This enzyme belongs to the family of oxidoreductases, specifically those acting on superoxide as acceptor (only sub-subclass identified to date). The systematic name of this enzyme class is rubredoxin:superoxide oxidoreductase. Other names in common use include neelaredoxin, and desulfoferrodoxin.
Structural studies
, 9 structures have been solved for this class of enzymes, with PDB accession codes,,,,,,,, and .
Further reading
- Jenney FE, Verhagen MF, Cui X, Adams MW . 1999 . Anaerobic microbes: oxygen detoxification without superoxide dismutase . Science . 286 . 306 - 9 . 10514376 . 10.1126/science.286.5438.306 . 5438 .
- Yeh AP, Hu Y, Jenney FE, Adams MW, Rees DC . 2000 . Structures of the superoxide reductase from Pyrococcus furiosus in the oxidized and reduced states . Biochemistry . 39 . 2499 - 508 . 10704199 . 10.1021/bi992428k . 10 .
- Lombard M, Fontecave M, Touati D, Niviere V . 2000 . Reaction of the desulfoferrodoxin from Desulfoarculus baarsii with superoxide anion. Evidence for a superoxide reductase activity . J. Biol. Chem. . 275 . 115 - 21 . 10617593 . 10.1074/jbc.275.1.115 . 1 . free . 1412.5038 . 7932649 .
- Teixeira M . 2000 . Oxygen detoxification in the strict anaerobic archaeon Archaeoglobus fulgidus: superoxide scavenging by neelaredoxin . Mol. Microbiol. . 38 . 322 - 34 . 11069658 . 10.1046/j.1365-2958.2000.02121.x . Saraiva . LM . Carita . J . Huber . H . Stetter . KO . Cabelli . D . Teixeira . M . 2 . 37827538 . free .
