Sulfopropanediol 3-dehydrogenase explained

Sulfopropanediol 3-dehydrogenase
Ec Number:	1.1.1.308

Sulfopropanediol 3-dehydrogenase (DHPS 3-dehydrogenase (sulfolactate forming), 2,3-dihydroxypropane-1-sulfonate 3-dehydrogenase (sulfolactate forming), dihydroxypropanesulfonate 3-dehydrogenase, hpsN (gene)) is an enzyme with systematic name (R)-2,3-dihydroxypropane-1-sulfonate:NAD⁺ 3-oxidoreductase.^[1] This enzyme catalyses the following chemical reaction

(R)-2,3-dihydroxypropane-1-sulfonate + 2 NAD⁺ + H₂O

\rightleftharpoons (R)-3-sulfolactate + 2 NADH + 2 H⁺

The enzyme is involved in degradation of (R)-2,3-dihydroxypropanesulfonate.

Notes and References

1. Mayer J, Huhn T, Habeck M, Denger K, Hollemeyer K, Cook AM . 2,3-Dihydroxypropane-1-sulfonate degraded by Cupriavidus pinatubonensis JMP134: purification of dihydroxypropanesulfonate 3-dehydrogenase . Microbiology . 156 . Pt 5 . 1556–64 . May 2010 . 20150239 . 10.1099/mic.0.037580-0 . free .