Sulfoacetaldehyde dehydrogenase (acylating) explained

Sulfoacetaldehyde dehydrogenase (acylating)
Ec Number:	1.2.1.81

Sulfoacetaldehyde dehydrogenase (acylating) (SauS) is an enzyme with systematic name 2-sulfoacetaldehyde:NADP⁺ oxidoreductase (CoA-acetylating).^[1] This enzyme catalyses the following chemical reaction

2-sulfoacetaldehyde + CoA + NADP⁺

\rightleftharpoons

sulfoacetyl-CoA + NADPH + H⁺

The enzyme is involved in degradation of sulfoacetate.

Notes and References

Weinitschke S, Hollemeyer K, Kusian B, Bowien B, Smits TH, Cook AM . Sulfoacetate is degraded via a novel pathway involving sulfoacetyl-CoA and sulfoacetaldehyde in Cupriavidus necator H16 . The Journal of Biological Chemistry . 285 . 46 . 35249–54 . November 2010 . 20693281 . 2975148 . 10.1074/jbc.M110.127043 . free .