Sulfite reductase (NADPH) explained

Sulfite reductase (NADPH)
Ec Number:	1.8.1.2
Cas Number:	9029-35-0
Width:	270

Sulfite reductase (NADPH) (sulfite (reduced nicotinamide adenine dinucleotide phosphate) reductase, NADPH-sulfite reductase, NADPH-dependent sulfite reductase, H₂S-NADP oxidoreductase, sulfite reductase (NADPH₂)) is an enzyme with systematic name hydrogen-sulfide:NADP⁺ oxidoreductase.^{[1] [2] [3]} This enzyme catalises the following chemical reaction

hydrogen sulfide + 3 NADP⁺ + 3 H₂O

\rightleftharpoons sulfite + 3 NADPH + 3 H⁺

Sulfite reductase is an iron flavoprotein (FAD and FMN).

Notes and References

1. Hilz H, Kittler M, Knape G . [The reduction of sulfate in yeast] . Biochemische Zeitschrift . 332 . 151–66 . 1959 . 14401842 .
2. Siegel LM, Murphy MJ, Kamin H . Reduced nicotinamide adenine dinucleotide phosphate-sulfite reductase of enterobacteria. I. The Escherichia coli hemoflavoprotein: molecular parameters and prosthetic groups . The Journal of Biological Chemistry . 248 . 1 . 251–64 . January 1973 . 10.1016/S0021-9258(19)44469-4 . 4144254 . free .
3. Yoshimoto A, Sato R . Studies on yeast sulfite reductase. I. Purification and characterization . Biochimica et Biophysica Acta . 153 . 3 . 555–75 . April 1968 . 4384979 . 10.1016/0005-2728(68)90185-0 .