Sulfanegen Explained

Sulfanegen is an experimental antidote for cyanide poisoning.[1] It is being studied as a prodrug for 3-mercaptopyruvic acid (3-MP). 3-MP has been studied as a potential treatment for cyanide poisoning, but the half-life is too short for it to be clinically effective.[2] Instead, alternative chemicals such as sulfanegen, the hemithioacetal cyclic dimer of 3-MP, are being evaluated that produce 3-MP in vivo to compensate for the short half-life of 3-MP itself.[3]

Sulfanegen has been shown to be effective in animal studies.[4] It is being studied as the disodium salt, sulfanegen sodium,[5] and the triethanolamine salt, sulfanegen TEA.[6] One advantage various sulfanegen formulations have over existing treatments for acute cyanide poisoning is that they might be administered by intramuscular injection or orally[1] rather than by intravenous infusion.[6]

Notes and References

  1. Web site: Scientists Discover Fast-Acting Cyanide Antidote . Dec 27, 2007 . . 2015-07-12 .
  2. 12871026 . 2003 . Nagahara . N . Li . Q . Sawada . N . Do antidotes for acute cyanide poisoning act on mercaptopyruvate sulfurtransferase to facilitate detoxification? . 3 . 3 . 198–204 . Current Drug Targets. Immune, Endocrine and Metabolic Disorders . 10.2174/1568008033340162.
  3. 20705081 . 2010 . Brenner . M . Kim . JG . Lee . J . Mahon . SB . Lemor . D . Ahdout . R . Boss . GR . Blackledge . W . Jann . L . Nagasawa . HT . Patterson . SE . Sulfanegen sodium treatment in a rabbit model of sub-lethal cyanide toxicity . 248 . 3 . 269–76 . 10.1016/j.taap.2010.08.002 . 3382974 . Toxicology and Applied Pharmacology.
  4. 21740135 . 2011 . Chan . A . Crankshaw . DL . Monteil . A . Patterson . SE . Nagasawa . HT . Briggs . JE . Kozocas . JA . Mahon . SB . Brenner . M . Pilz . RB . Bigby . TD . Boss . GR . The combination of cobinamide and sulfanegen is highly effective in mouse models of cyanide poisoning . 49 . 5 . 366–73 . 10.3109/15563650.2011.584879 . . 3882312.
  5. 22392971 . 2012 . Belani . KG . Singh . H . Beebe . DS . George . P . Patterson . SE . Nagasawa . HT . Vince . R . Cyanide toxicity in juvenile pigs and its reversal by a new prodrug, sulfanegen sodium . 114 . 5 . 956–61 . 10.1213/ANE.0b013e31824c4eb5 . 3334426 . Anesthesia and Analgesia.
  6. News: New Antidote for Cyanide Found . Yahoo News . February 1, 2013.

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