Succinylglutamate desuccinylase explained

succinylglutamate desuccinylase
Ec Number:	3.5.1.96
Go Code:	0009017

In enzymology, a succinylglutamate desuccinylase is an enzyme that catalyzes the chemical reaction

N-succinyl-L-glutamate + H₂O

\rightleftharpoons succinate + L-glutamate

Thus, the two substrates of this enzyme are N-succinyl-L-glutamate and H₂O, whereas its two products are succinate and L-glutamate.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is N-succinyl-L-glutamate amidohydrolase. Other names in common use include N2-succinylglutamate desuccinylase, SGDS, and AstE. This enzyme participates in arginine and proline metabolism.

References

• Vander Wauven C, Stalon V . 1985 . Occurrence of succinyl derivatives in the catabolism of arginine in Pseudomonas cepacia . J. Bacteriol. . 164 . 882 - 6 . 2865249 . 2 . 214334 .
• Cunin R, Glansdorff N, Pierard A, Stalon V . 1986 . Biosynthesis and metabolism of arginine in bacteria . Microbiol. Rev. . 50 . 314 - 52 . 3534538 . 3 . 373073 .
• Cunin R, Glansdorff N, Pierard A, Stalon V . 1987 . Erratum report: Biosynthesis and metabolism of arginine in bacteria . Microbiol. Rev. . 51 . 1 . 178 . 16350242 . 373097 .
• Itoh Y . 1997 . Cloning and characterization of the aru genes encoding enzymes of the catabolic arginine succinyltransferase pathway in Pseudomonas aeruginosa . J. Bacteriol. . 179 . 7280 - 90 . 9393691 . 23 . 179677 . 10.1128/jb.179.23.7280-7290.1997.
• Schneider BL, Kiupakis AK, Reitzer LJ . 1998 . Arginine catabolism and the arginine succinyltransferase pathway in Escherichia coli . J. Bacteriol. . 180 . 4278 - 86 . 9696779 . 16 . 107427 .