Succinyl-CoA:(R)-benzylsuccinate CoA-transferase explained

Succinyl-CoA:(R)-benzylsuccinate CoA-transferase
Ec Number:	2.8.3.15

In enzymology, a succinyl-CoA:(R)-benzylsuccinate CoA-transferase is an enzyme that catalyzes the chemical reaction

succinyl-CoA + (R)-2-benzylsuccinate

\rightleftharpoons succinate + (R)-2-benzylsuccinyl-CoA

Thus, the two substrates of this enzyme are succinyl-CoA and (R)-2-benzylsuccinate, whereas its two products are succinate and (R)-2-benzylsuccinyl-CoA.

This enzyme belongs to the family of transferases, specifically the CoA-transferases. The systematic name of this enzyme class is succinyl-CoA:(R)-2-benzylsuccinate CoA-transferase. This enzyme is also called benzylsuccinate CoA-transferase. This enzyme participates in benzoate degradation via coa ligation.

References

• Leutwein C, Heider J . 2001 . Succinyl-CoA:(R)-benzylsuccinate CoA-transferase: an enzyme of the anaerobic toluene catabolic pathway in denitrifying bacteria . J. Bacteriol. . 183 . 4288–95 . 11418570 . 10.1128/JB.183.14.4288-4295.2001 . 14 . 95319 .
• Leutwein C, Heider J . Anaerobic toluene-catabolic pathway in denitrifying Thauera aromatica: activation and beta-oxidation of the first intermediate, (R)-(+)-benzylsuccinate . Microbiology . 145 . 3265–71 . 10589736 . 10.1099/00221287-145-11-3265. free.
• Leuthner B, Heider J . 2000 . Anaerobic toluene catabolism of Thauera aromatica: the bbs operon codes for enzymes of beta oxidation of the intermediate benzylsuccinate . J. Bacteriol. . 182 . 272–7 . 10629170 . 10.1128/JB.182.2.272-277.2000 . 2 . 94273 .
• Heider J . 2001 . A new family of CoA-transferases . FEBS Lett. . 509 . 345–9 . 11749953 . 10.1016/S0014-5793(01)03178-7 . 3 . free .