Succinate-semialdehyde dehydrogenase (acylating) explained

Succinate-semialdehyde dehydrogenase (acylating)
Ec Number:	1.2.1.76

Succinate-semialdehyde dehydrogenase (acylating) (succinyl-coA reductase, coenzyme-A-dependent succinate-semialdehyde dehydrogenase) is an enzyme with systematic name succinate semialdehyde:NADP⁺ oxidoreductase (CoA-acylating).^{[1] [2] [3]} This enzyme catalyses the following chemical reaction

succinate semialdehyde + CoA + NADP⁺

\rightleftharpoons succinyl-CoA + NADPH + H⁺

Catalyses the NADPH-dependent reduction of succinyl-CoA to succinate semialdehyde.

Notes and References

1. Söhling B, Gottschalk G . Purification and characterization of a coenzyme-A-dependent succinate-semialdehyde dehydrogenase from Clostridium kluyveri . European Journal of Biochemistry . 212 . 1 . 121–7 . February 1993 . 8444151 . 10.1111/j.1432-1033.1993.tb17641.x . free .
2. Alber B, Olinger M, Rieder A, Kockelkorn D, Jobst B, Hügler M, Fuchs G . Malonyl-coenzyme A reductase in the modified 3-hydroxypropionate cycle for autotrophic carbon fixation in archaeal Metallosphaera and Sulfolobus spp . Journal of Bacteriology . 188 . 24 . 8551–9 . December 2006 . 17041055 . 1698253 . 10.1128/JB.00987-06 .
3. Berg IA, Kockelkorn D, Buckel W, Fuchs G . A 3-hydroxypropionate/4-hydroxybutyrate autotrophic carbon dioxide assimilation pathway in Archaea . Science . 318 . 5857 . 1782–6 . December 2007 . 18079405 . 10.1126/science.1149976 .