Succinate-semialdehyde dehydrogenase (NADP+) explained

Succinate-semialdehyde dehydrogenase (NADP+)
Ec Number:	1.2.1.79

Succinate-semialdehyde dehydrogenase (NADP⁺) (succinic semialdehyde dehydrogenase (NADP⁺), succinyl semialdehyde dehydrogenase (NADP⁺), succinate semialdehyde:NADP⁺ oxidoreductase, NADP-dependent succinate-semialdehyde dehydrogenase, GabD) is an enzyme with systematic name succinate-semialdehyde:NADP⁺ oxidoreductase.^{[1] [2]} This enzyme catalyses the following chemical reaction

succinate semialdehyde + NADP⁺ + H2O

\rightleftharpoons succinate + NADPH + 2 H⁺

This enzyme participates in the degradation of glutamate and 4-aminobutyrate.

Notes and References

1. Bartsch K, von Johnn-Marteville A, Schulz A . Molecular analysis of two genes of the Escherichia coli gab cluster: nucleotide sequence of the glutamate:succinic semialdehyde transaminase gene (gabT) and characterization of the succinic semialdehyde dehydrogenase gene (gabD) . Journal of Bacteriology . 172 . 12 . 7035–42 . December 1990 . 2254272 . 210825 . 10.1128/jb.172.12.7035-7042.1990.
2. Jaeger M, Rothacker B, Ilg T . Saturation transfer difference NMR studies on substrates and inhibitors of succinic semialdehyde dehydrogenases . Biochemical and Biophysical Research Communications . 372 . 3 . 400–6 . August 2008 . 18474219 . 10.1016/j.bbrc.2008.04.183 .